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  • We mapped the fate of disease-associated microglia(DAM), revealing that neonatal DAM retain a persistent immune memory——priming the brain for heightened responses to later challenges.

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  • We uncovered an astrocyte-microglia immune crosstalk that interfaces with developing neuronal circuits during the postnatal period.

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  • We found that the brain's protective lining(the meninges) supports its own B cell development.

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2015 - today (Peer-reviewed Publications)

[1] Wang Y，Xu D，Liu S，Li H，Wang Y，Li H，Xu H，He D.Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse.Immunity. 2025 July 15.doi.org/10.1016/j.immuni.2025.06.016.(Corresponding author)

[2] Kimura K,Subramanian A,Yin Z,Khalilnezhad A,Wu Y,He D,Dixon KO,Chitta UK,Ding X,Adhikari N,Guzchenko I,Zhang X,Tang R,Pertel T,Myers SA,Aastha A,Nomura M, Eskandari-Sedighi G,Singh V,Liu L,Lambden C,Kleemann KL,Gupta N,Barry JL,Durao A,Cheng Y,Silveira S,Zhang H,Suhail A,Delorey T,Rozenblatt-Rosen O,Freeman GJ,Selkoe DJ,Weiner HL,Blurton-Jones M,Cruchaga C,Regev A,Suvà ML,Butovsky O & Kuchroo VK.Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease.Nature. 2025 Apr 9.

[3] Yang R,He D. Gut know-how: IL-22 from T cells boosts stress resilience.Immunity. 2025 Jan 14;58(1):10-12. doi:10.1016/j.immuni.202411.022.(Corresponding author)

[4] Lan Y,Zhang X,Liu S,Guo C,Jin Y,Li H,Wang L,Zhao J,Hao Y,Li Z,Liu Z,Ginhoux F,Xie Q,Xu H,Jia J,He D. Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury.Immunity.2024 Feb 13;57(2):349-363.e9.doi:10.1016/j.immuni.2024.01.008.Epub 2024 Feb2.(Corresponding author)

[5] He D,Xu H,Zhang H,Tang R,Lan Y,Xing R,Li S,Christian E,Hou Y,Lorello P,Caldarone B,Ding J,Nguyen L,Dionne D,Thakore P,Schnell A,Huh JR,Rozenblatt-Rosen O,Regev A,Kuchroo VK. Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function. Immunity. 2022 Jan 11;55(1):159-173.e9.doi:10.1016/j.immuni.2021.12.001.Epub 2022 Jan 3.(Co-corresponding author)

[6] Wang Y,Chen D,Xu D,Huang C,Xing R,He D,Xu H. Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges. Immunity. 2021 Dec 14;54(12):2784-2794.e6. doi: 10.1016/j.immuni.2021.09.016.Epub 2021 Oct 8.(Co-corresponding author)

[7] Weng Q,Wang J,Wang J,He D,Cheng Z,Zhang F,Verma R,Xu L,Dong X,Liao Y,He X,Potter A,Zhang L,Zhao C,Xin M,Zhou Q,Aronow BJ,Blackshear PJ,Rich JN,He Q,Zhou W,Suvà ML,Waclaw RR,Potter SS,Yu G,Lu QR. Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell Stem Cell. 2019 May 2;24(5):707-723.e8. doi: 10.1016/j.stem.2019.03.006.Epub 2019 Apr 11.(Corresponding author)

[8] He D,Wang J,Lu Y,Deng Y,Zhao C,Xu L,Chen Y,Hu YC,Zhou W, Lu QR. lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. Neuron. 2017 Jan 18;93(2):362-378. doi:20.1016/j.neuron.2016.11.044.Epub 2016 Dec 29.

[9] He D,Marie C,Zhao C,Kim B,Wang J,Deng Y,Clavairoly A,Frah M,Wang H,He X,Hmidan H,Jones BV,Witte D,Zalc B,Zhou X,Choo DI,Martin DM,Parras C,Lu QR. Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.Nat Neurosci. May;19(5):678-689. doi:10.1038/nn.4258. Epub 2016 Feb 29.2025 Apr 9.